Made
GRM3
Locus Rank
44

Gene

Id
188
Gene Name
GRM3
Duplicated
False
Maternal
False
Gene Not Within Locus (Nearby
False
Gene Description
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Mouse Phenotype
Additional Image
Allen Brain
Allen Regions
Zfin In Situ
Zfin Brain Areas
caudal tuberculum dorsal region, caudal tuberculum ventral region, caudal tuberculum ventro-lateral region, corpus cerebelli, dorsal telencephalon, fourth ventricle, habenula, hypothalamus lateral recess, hypothalamus posterior region, inferior olive, intermediate hypothalamus, retinal ganglion cell layer, retinal inner nuclear layer, superior raphe nucleus, tectal ventricle, telencephalic ventricle, valvula cerebelli
Published Zebrafish Pehnotype
Not In Allen Brain
False
ZFIN Link
http://zfin.org/ZDB-GENE-061009-13
Allen Link
None
More Additional Images
Papers
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681425/
http://www.ncbi.nlm.nih.gov/pubmed/25179095

Locus Rank

Locus Rank
44
Genes in Region
GRM3
Associated Snps
rs12704290
GWAS Region (hg19)
chr7:86403226-86459326
Genes Skipping
Ricopili Plot Surrounding Area
Distance On Each Side Of Locus In Above Plot
1 MB
Ricopili Plot
Gwas And Surrounding Region Pic
Gwas Region Pic
Genes In Locus Rank
GRM3

Sequence 1

Ensembl Gene Name
grm3
Harvard Allele
a281
Mutation Area - WT DNA Sequence
ACCAGGCCAAGGCCATGGCGGAGATCTTACGGGCCTTCAACTGGACCTACGTTTCCACCGTGGCCTCAGAGGGAGACTATGGAGAAACAGGAATCGAAGCCTTCGAGCAACAAGCGCGTTTGAGAAACATCTGCATCGCTACTTCGGAAAAAGTAGGACGATCTAGCGCAAAGCGTTCTTCATATGAGGCCGTGGTCCGCCAGCTCCTCCAGAAGCCCACAGCTCGCGTCGCTGTTCTTTTTCTACGTAGCGACGACGCAAGAGAACTAATCGCCGCTGCCGCCCGCCTCAACGCATCTTTCCTCTGGGTGGCCAGCGACGGATGGGGGGCGCAAGAGAGCATCGTCAAAGGGAACGAATTCACAGCAGATGGTGCAATCACGCTGGAGCTAGCGGCTCATCCCATACCAGATTTCAACCGTTACTTCCAGACCCTCACGCCCCAAATTAACCATCGCAACCCCTGGTTCAAAGACTTCTGGGAGCAAAAGTTTCAGTGTTCATTGGGTGGGACGTCAGCAACAGGGGCAGGAACCCCAAAGCCACCTTGTGACCAGGAACTGGTTATCGACAAGTCCAATTTTGAGCCAGAATCAAAGATTATGTTTGTGGTAAATGCAGTGTATGCCATGGCGCATGCTTTGCATCGCATGCAACGGACTTTGTGTGCCAACACTACACGTTTGTGTGATGCCATGCGCAGTCTTG
Mutation Area - Mutant DNA Sequence
ACCAGGCCAAGGCCATGGCGGAGATCTTACGGGCCTTCAACTGGACCTACGTTTCCACCGTGGCCTCAGAGGGAGACTATGGAGAAACAGGAATCGAAGCCTTCGAGCAACAAGCGCGTTTGAGAAACATCTGCATCGCTACTTCGGAAAAAGTAGGACGATCGAGCGCAAAGCGTTCTTCATATGAGGCCGTGGTCCGCCAGCTCCTCCAGAAGCCCACAGCTCGCGTCGCTGTTCTTTTTCTACGTAGCGACGACGCAAGAGAACTAATCGCCGCTGCCGCCCGCCTGTGACCAGGAACTGGTTATCGACAAGTCCAATTTTGAGCCAGAATCAAAGATCATGTTTGTGGTAAATGCGGTGTATGCCATGGCGCATGCTTTGCATCGCATGCAACGGACTTTGTGTGCCAACACTACACGTTTGTGTGATGCCATGCGCAGTCTTG
Guide RNA Target Sites
GCGTTCTTCATATGAGGCCGTGG
AGAGGAAAGATGCGTTGAGGCGG
TGCAATCACGCTGGAGCTAGCGG
ACCAGTTCCTGGTCACAAGGTGG
Genotyping Primers
f, ACCAGGCCAAGGCCATGGCGG
r, CAAGACTGCGCATGGCATCACAC
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence
Allele
260bpD
WT Genotyping Size
708
WT Protein Sequence
MWSAVRALLLLSAGLLQSRGDSPRKEIKIDGDLVLGGLFPIHEKGMGMDECGRINEDRGI
QRLEAMLFAIDQINQDVALLPGVVLGVHILDTCSRDTYALEQALEFVRASLTKVDDTEFI
CPDGSYALQEDSPLAIAGVIGGSFSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFYQAKAMAEILRAFNWTYVSTVASEGDYGETGIEAFEQQARLRNICIATSEK
VGRSSAKRSSYEAVVRQLLQKPTARVAVLFLRSDDARELIAAAARLNASFLWVASDGWGA
QESIVKGNEFTADGAITLELAAHPIPDFNRYFQTLTPQINHRNPWFKDFWEQKFQCSLGG
TSATGAGTPKPPCDQELVIDKSNFEPESKIMFVVNAVYAMAHALHRMQRTLCANTTRLCD
AMRSLDGRKLYRDFLLHVNFRAPFSPAGLESQVKFDAYGDGVGRYNIFNYQSVPGSDKFA
YVQVGEWAESLSLNEGLIGWPRGADVPTSQCSDPCAPNEMKKMQAGEYCCWICTPCEPYE
YLPDEFTCMPCAPGQWPRPDLTGCYDLPEDYIMWEDAWAIGPISIACVGFICTLMVFIVF
IRHNDTPLVKASGRELCYILLLGVFMSYVMTFIFIAKPSPIVCTLRRLGLGTSFAVCYSA
LLTKTNRIARIFSGVKEGGAQRPRFISPSSQVFICLSLISVQLLLVSVWLLVEVPGTRRF
TTPEKRQTVILKCNVRDSSMLMSLSYDVVLVVLCTVYAFKTRKCPENFNEAKFIGFTMYT
TCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCMFAPKVHIIMFQPQKNVTSH
RLNMNRFSVSGPATSYASHASVSAHYVPTVCNGREIVDSTTSSL-
Mutant Protein Sequence
MWSAVRALLLLSAGLLQSRGDSPRKEIKIDGDLVLGGLFPIHEKGMGMDECGRINEDRGI
QRLEAMLFAIDQINQDVALLPGVVLGVHILDTCSRDTYALEQALEFVRASLTKVDDTEFI
CPDGSYALQEDSPLAIAGVIGGSFSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFYQAKAMAEILRAFNWTYVSTVASEGDYGETGIEAFEQQARLRNICIATSE
KVGRSSAKRSSYEAVVRQLLQKPTARVAVLFLRSDDARELIAAAARL-
Mutant Genotyping Size
448
Ribosome Profiling Development

Behavior Data

Behavior Data Summary
None
Behavior Data Description 1
Dark flash block 1 start Merged section Pvalue = not significant 29 wt vs 18 hom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png
Behavior Data Graph 1
Behavior Data Description 2
Day all prepulse tap Merged section Pvalue = not significant 29 wt vs 18 hom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png
Behavior Data Graph 2
Behavior Data Description 3
Features of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 29 wt vs 18 hom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png
Behavior Data Graph 3
Behavior Data Description 4
Frequency of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 29 wt vs 18 hom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png
Behavior Data Graph 4
Behavior Data Description 5
Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 29 wt vs 18 hom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png
Behavior Data Graph 5
Behavior Data Description 6
Features of movement Graph Pvalue = 0.008 22 het vs 20 hom ribgraph_mean_ribbonbout_aveboutcumdpix_min_day1day.png
Behavior Data Graph 6
Behavior Data Description 7
Strong tap Graph Pvalue = 0.000942 35 het vs 18 hom boxgraph_pd__bigmovesribgraph_mean_ribbon_peakspeed_adaytappostbdaytappre102.png
Behavior Data Graph 7
Behavior Data Description 8
None
Behavior Data Graph 8
None
Behavior Data Description 9
None
Behavior Data Graph 9
None
Behavior Data Description 10
None
Behavior Data Graph 10
None
Behavior Data Description 11
None
Behavior Data Graph 11
None
Behavior Data Description 12
None
Behavior Data Graph 12
None
Behavior Data Description 13
None
Behavior Data Graph 13
None
Behavior Data Description 14
None
Behavior Data Graph 14
None