schizophrenia gene search

Made

GTDC1

Locus Rank

Gene

276

Gene Name

GTDC1

Duplicated

False

Maternal

False

Gene Not Within Locus (Nearby

True

Gene Description

Mouse Phenotype

Additional Image

Allen Brain

Allen Regions

Zfin In Situ

Zfin Brain Areas

Published Zebrafish Pehnotype

Not In Allen Brain

False

ZFIN Link

None

Allen Link

None

More Additional Images

Papers

Locus Rank

Genes in Region

No genes within locus (gene desert). Both ZEB2 and GTDC1 are nearby.

Associated Snps

GWAS Region (hg19)

chr2:146416922-146441832

Genes Skipping

ZEB2, but it is a likely candidate and should be tested.

Ricopili Plot Surrounding Area

Distance On Each Side Of Locus In Above Plot

Ricopili Plot

Gwas And Surrounding Region Pic

Gwas Region Pic

Genes In Locus Rank

GTDC1

Sequence 1

Ensembl Gene Name

gtdc1

Harvard Allele

a374

Mutation Area - WT DNA Sequence

gatctctgcagtaaatagcctgcgtccATGAGTGTGCTCTTGCTGGAGGCGTTCTATGGCGGCTCCCACAAACAGCTGCTTGATCTTCTCAAGGAAAGTGTTGAAGACTGTGTGAGCTTCACTCTGCCTGCGAAAAAATGGCACTGGAGAGCCAGAACCTCTGCTCTGTACTTCATGCAAGCAGTTCCAGCAAATTCCTCATACAGgtcggcaaaaatcaccacactgattttgtgcaataaaggaattgtata

Mutation Area - Mutant DNA Sequence

GATCTCTGCAGTAAATAGCCTGCGTCCATGAGTGTGCTCTTGCTGGAGGCGTTCTAGCAAAGCAGTACTTCATGCAAGCAGTTCTAGCAAATTCTTCATACAGGTCGGCAAAAATCACCTCACTGATTTTGTGCAATAAAGGAATTGTATA

Guide RNA Target Sites

TTGCTGGAGGCGTTCTATGGCGG
GAAGATCAAGCAGCTGTTTGTGG
TTGCATGAAGTACAGAGCAGAGG
AGCAAATTCCTCATACAGgtcgg

Genotyping Primers

f, gatctctgcagtaaatagcctgcg
r, tatacaattcctttattgcacaaaatcagtg

Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

Allele

103bpD

WT Genotyping Size

254

WT Protein Sequence

MSVLLLEAFYGGSHKQLLDLLKESVEDCVSFTLPAKKWHWRARTSALYFMQAVPANSSYR
VLFTSSVLNLAELVALRPDLGHLKKVLYFHENQLVYPVRKSQERDFQYGYNQILSCLVAD
VVVFNSSFNMESFLSSISTFMKTMPDHRPKDLERLIRPKCHVLHFPIRFPDVTRFLPAHK
RLRHPVRCDDIHAPAAKSHIQTSSPSSYPDVEPPEKMLNVAGTNQSHEPTSVTPHQETAS
PLCGHEGEKLRPLHIVWPHRWEHDKDPQLFFQTLLKLKDRQLSFEVSVLGETFTDVPDIF
SEAKEQLVDHIQHWGFMPSKEDYLKVLCQADVVVSTAKHEFFGVAMLEAVHCGCYPLCPK
ALVYPEIFPATYLYSTPEQLCKRLQEFCKRPQLARQHVVQVSLSSFSWDSLGDNFRSLLK
ADSGRMFTDKHMA-

Mutant Protein Sequence

MSVLLLEAF-

Mutant Genotyping Size

151

Behavior Data

Behavior Data Summary

None

Behavior Data Description 1

Dark flash block 1 start Merged section Pvalue = not significant 15 het vs 16 hom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png

Behavior Data Graph 1

Behavior Data Description 2

Day all prepulse tap Merged section Pvalue = not significant 15 het vs 16 hom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png

Behavior Data Graph 2

Behavior Data Description 3

Features of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 15 het vs 16 hom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png

Behavior Data Graph 3

Behavior Data Description 4

Frequency of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 15 het vs 16 hom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png

Behavior Data Graph 4

Behavior Data Description 5

Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 15 het vs 16 hom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png

Behavior Data Graph 5

Behavior Data Description 6

None

Behavior Data Graph 6

None

Behavior Data Description 7

None

Behavior Data Graph 7

None

Behavior Data Description 8

None

Behavior Data Graph 8

None

Behavior Data Description 9

None

Behavior Data Graph 9

None

Behavior Data Description 10

None

Behavior Data Graph 10

None

Behavior Data Description 11

None

Behavior Data Graph 11

None

Behavior Data Description 12

None

Behavior Data Graph 12

None

Behavior Data Description 13

None

Behavior Data Graph 13

None

Behavior Data Description 14

None

Behavior Data Graph 14

None