Locus Rank
15Gene
Id
148Gene Name
LRRN3Duplicated
TrueMaternal
FalseGene Not Within Locus (Nearby
TrueGene Description
Mouse Phenotype
Homozygous null mutant mice exhibited increased mean percent body fat and male homozygous mutant mice exhibited enhanced glucose tolerance when compared with controls.Additional Image
Allen Brain
Allen Regions
Zfin In Situ
Zfin Brain Areas
Published Zebrafish Pehnotype
Not In Allen Brain
FalseZFIN Link
http://zfin.org/ZDB-GENE-061220-7Allen Link
http://mouse.brain-map.org/gene/show/16751More Additional Images
Papers
http://www.ncbi.nlm.nih.gov/pubmed/25300143Locus Rank
Locus Rank
15Genes in Region
IMMP2L (directly in locus), LRRN3, DOCK4Associated Snps
rs13240464
rs211829
GWAS Region (hg19)
chr7:110843815-111205915Genes Skipping
DOCK4 - possible, but is much farther away from locus than the other two genes and is also involved in cancer and seems to have many important biological roles unrelated to neurons.Ricopili Plot Surrounding Area
Distance On Each Side Of Locus In Above Plot
1 MBRicopili Plot
Gwas And Surrounding Region Pic
Gwas Region Pic
Sequence 1
Ensembl Gene Name
LRRN3 (1 of many)Harvard Allele
a294Mutation Area - WT DNA Sequence
GACCCTGGTTTTCCCCTAGCTCTGTCTATATGGAGGCTCCCACGATTGATTGTAATGACCTGGGACTTTTTAAACTACCCACGAGATTGCCATTAGATACACAAGTTCTTTTACTTCAGACCAATAATATTGCTAAAAACGAGCACCCTTTGGATTATCTGACCAACATCACTGAGATTGATCTCTCGCAAAACMutation Area - Mutant DNA Sequence
GACCCTGGTTTTCCCCTAGCTCTGTCTATATGGAGGCTCCCACGATTGATTGTAATGACCTGGGACTTTTTAAACTACCCACTTTTAGTTCTTTTACTTCAGACCAATAATATTGCTAAAAACGAGCACCCTTTGGATTATCTGACCAACATCACTGAGATTGATCTCTCGCAAAACGuide RNA Target Sites
TGTATCTAATGGCAATCTCGTGGGenotyping Primers
f, GACCCTGGTTTTCCCCTAGCTCTGTC
r, GTTTTGCGAGAGATCAATCTCAGTGATG
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence
Allele
17bpDWT Genotyping Size
194WT Protein Sequence
MKDISFMDYLLVGLAMATFVIAAEEKISCPKLCVCEIRPWFSPSSVYMEAPTIDCNDLGL
FKLPTRLPLDTQVLLLQTNNIAKNEHPLDYLTNITEIDLSQNNLSSINDINIGSLPQLLS
LHMEENWICSLPDNSLSQLTNLQELYLNHNLISLISPEAFRGLQSLLRLHLNSNRLQIIK
SEWFEPLPNLEILMIGENPVLSIQDMNFKPLRNLRSLVLTRMNLSQIPDDSFLGLDNLES
ISFYDNTFPKVPHGALRHLKSLKFLDLNKNPIGRIQRGDFVDMLHLKELGINSMPELVSI
DSFALNNLPELTKIEATNNPKLSYIHPNAFYRLPRLETLMLNGNALSALHRITVESLPNL
REVSMHSNPIRCDCVVRWMNMNKTNIRFMEPDSLFCVEPPEYEGQHVRQVHFREMMEICL
PLISSESLPTQISMDRGRSVSLHCRAFAEPEPDIYWVTPSGRRVIPNAVFERFYMHPEGT
LDIYDITENEAGLYTCVAHNLVGADLKSVSVQVNGYFPQPVNDSLYVSVQSVQTHSVLIT
WKASHGSLAPNIKWYTMPGANYPTVAFTARVPSDVTLYNLTHLSPATQYKVCVDIHSVHR
NHDTKCVNVLTKGLEQIVNDSESWDMALIAAFGVLFIVMSVACFLIYMFMRNHCIYGELK
RCPSNTALMSETSQQSPFTRLWISGKGMPAAVEVKATVINVLDNAF-
Mutant Protein Sequence
MKDISFMDYLLVGLAMATFVIAAEEKISCPKLCVCEIRPWFSPSSVYMEAPTIDCNDLGLFK
LPTFSSFTSDQ-
In Situ Probe Sequence
GCTTGTGGGCCTTGCAATGGCAACGTTTGTTATTGCTGCAGAGGAGAAAATCAGTTGTCCAAAACTTTGTGTATGTGAAATCAGACCCTGGTTTTCCCCTAGCTCTGTCTATATGGAGGCTCCCACGATTGATTGTAATGACCTGGGACTTTTTAAACTACCCACGAGATTGCCATTAGATACACAAGTTCTTTTACTTCAGACCAATAATATTGCTAAAAACGAGCACCCTTTGGATTATCTGACCAACATCACTGAGATTGATCTCTCGCAAAACAACCTATCATCAATAAATGACATCAATATTGGCTCTCTCCCTCAACTCTTATCCCTGCACATGGAGGAAAACTGGATATGTTCCCTACCAGACAACAGCCTTTCCCAACTGACCAACCTTCAGGAGCTCTACCTGAATCACAACCTCATCTCCTTAATTTCTCCCGAGGCTTTCCGTGGCCTTCAGAGCCTCCTGAGACTGCATCTCAACTCCAACCGTCTTCAGATCATAAAAAGTGAATGGTTTGAGCCACTACCAAATTTGGAAATTCTAATGATTGGGGAAAATCCTGTCCTTTCTATTCAGGATATGAACTTCAAGCCTTTGAGAAACCTGCGCAGCCTGGTTCTTACTAGAATGAACCTGTCCCAGATACCAGATGACTCATTTCTGGGTCTTGACAACCTAGAGAGCATCTCATTCTATGATAATACATTCCCTAAGGTGCCCCATGGTGCTCTCAGGCATCTTAAGAGCCTCAAGTTTTTGGATCTTAACAAGAACCCAATTGGAAGAATTCAAAGGGGTGACTTTGTGGACATGCTGCACCTTAAGGAGCTGGGCATTAACAGTATGCCTGAGTTGGTGTCAATTGATAGTTTTGCCCTCAACAACCTCCCAGAACTGACCAAAATTGAAGCTACGAACAACCCAAAACTTTCCTATATACATCCTAATGCCTTCTATAGGCTACCGAGGCTMutant Genotyping Size
177Sequence 2
Ensembl Gene Name
lrrn3Harvard Allele
a295Mutation Area - WT DNA Sequence
GTTTGCAGTTTGTTTGCTGGCAGGACTCGCACTGACGAACTCAGTTCAGGCCTCTAAGTGGAGTGTTGTGTGCCTCAAGCTGTGCAAATGTGAAATCCGACCCTGGTTCTCTCCCTTGTCCATGTATAATGAGGCTCCGACTGTGGACTGTAATGATCTAGGACTTTTGACTCTGCCGGAGAGGTTGCCTTCAGACACACAAGTACTTCTATCACAAGCAAACAGCATTGCAAAGATTGACAGTCCCTTGGACTACCTGGTAAACCTAACTGAGGTAGACCTATCTCGAAATAACATATCCTCACTGAGTGATATATATATAGGTCACATTCCACAACTTTTGTCTTTGCACCTAGAAGAGAACTGGCTAAGCAGCCTTCATGATAATTTCCTTGCACACTTTCCAAACTTGCAAGAGCTCTATGTTAACCATAACCTACTCTCCTTGATCAGTGCAGAGGCTTTCCAAGGGCTTAATAAGCTCTTGAGGCTTCATCTTAATTCCAACCAGCTAAGAGCCATAAGATCAGAGTGGTTCCAGGATCTTTCCCAGCTAGAAATCTTGATGATAGGAGAGAATCCAATTGCCAGAATACAAAACATGAATTTCAAGCCCCTTATCAATCTCCGCAGTCTTGTGCTAACCAGAATGAACCTCACTGAAATCCCTGACAGTGCCCTGGTTGGCCTTGATAAGCTAGAAAGCGTGTCATTCTATGATAATATGTTCCCAAAAGTACCTCAAGCTGCTCTCAGACAAGTGCGGAACCTCAAATTTCTGGACCTTAACAAGAATCCCATCGAGAGGATCCAAAGGGGTGACTTTGTCGACATGATCCATTTGAAAGAACTTGGTATTAACAGCATGCCAGAGTTAGTTTCAATCGACAGCTTCGCCTTGCATAACCTACCAGAGCTTACCAAAATCGAAGCCMutation Area - Mutant DNA Sequence
GTTTGCAGTTTGTTTGCTGGCAGGACTCAATTTCTGGACCTTAACAAGAATCCCATCGAGAGGATCCAAAGGGGTGACTTTGTCGACATGATCCATTTGAAAGAACTTGGTATTAACAGCATGCCAGAGTTAGTTTCAATCGACAGCTTCGCCTTGCATAACCTACCAGAGCTTACCAAAATCGAAGCCCGuide RNA Target Sites
ACTCAGTTCAGGCCTCTAAGTGG
GACTTTTGACTCTGCCGGAGAGG
TTCTGGTTAGCACAAGACTGCGG
AAGCTGCTCTCAGACAAGTGCGG
Genotyping Primers
f, GTTTGCAGTTTGTTTGCTGGCAGG
r, GGCTTCGATTTTGGTAAGCTCTGGTAGG
wt_f, CCTTATCAATCTCCGCAGTCTTGTGC
All three primers can be mixed together. These gene is designated as lrrn3b.
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence
Allele
744bpDWT Genotyping Size
319WT Protein Sequence
MKDLLFAVCLLAGLALTNSVQASKWSVVCLKLCKCEIRPWFSPLSMYNEAPTVDCNDLGL
LTLPERLPSDTQVLLSQANSIAKIDSPLDYLVNLTEVDLSRNNISSLSDIYIGHIPQLLS
LHLEENWLSSLHDNFLAHFPNLQELYVNHNLLSLISAEAFQGLNKLLRLHLNSNQLRAIR
SEWFQDLSQLEILMIGENPIARIQNMNFKPLINLRSLVLTRMNLTEIPDSALVGLDKLES
VSFYDNMFPKVPQAALRQVRNLKFLDLNKNPIERIQRGDFVDMIHLKELGINSMPELVSI
DSFALHNLPELTKIEATNNPRLSYIHPNAFSQLPRLESLMLNSNALRALHHITVESLPNL
QEVSIHSNPIYCDCVIRWINMNNTRVRFMELDALLCAGPSEFEGRLVKQVHSREMADICL
PLISPESLPDQVNVGTGHLVSLHCRAFADPEPEIYWVTPSGEKILPQMDSKKYHLHPEGT
FDIYGITENEAGQYTCVAHNLIGVDMRSVLVIVNGYYPLLVNESLHIQVENTEPNSVSIS
WVPPKGSLVSNIKWSTNSQHHSLQFTSHVVSNVKKFYLTNLHSLTQYEVCVEITDMQSRH
LKNCINVTTTEVSKRKNDDVINDGLIISLTAVLLIMSAVACSFICMLRRNDPLYRKLRNQ
QSEILPSHIKPNWRSRAKANDSETDLTKNSI-
Mutant Protein Sequence
MKDLLFAVCLLAGLNFWTLTRIPSRGSKGVTLST-In Situ Probe Sequence
GGTTGCAACTCTCTGCCAAGGACGATAACAGACAAAATCGCTGCTTTGGGGAACTTGCCATCAGCAGAAATACACCCATGTTGTCATAACAAATGATTCTGTGTTAGTGAATTTAACGCCTGGAACGCCAGACCCCATAAGGACCAATTACAAGCTGAAGAGAGCAGGACCAAGATGAAAGATTTGCTGTTTGCAGTTTGTTTGCTGGCAGGACTCGCACTGACGAACTCAGTTCAGGCCTCTAAGTGGAGTGTTGTGTGCCTCAAGCTGTGCAAATGTGAAATCCGACCCTGGTTCTCTCCCTTGTCCATGTATAATGAGGCTCCGACTGTGGACTGTAATGATCTAGGACTTTTGACTCTGCCGGAGAGGTTGCCTTCAGACACACAAGTACTTCTATCACAAGCAAACAGCATTGCAAAGATTGACAGTCCCTTGGACTACCTGGTAAACCTAACTGAGGTAGACCTATCTCGAAATAACATATCCTCACTGAGTGATATATATATAGGTCACATTCCACAACTTTTGTCTTTGCACCTAGAAGAGAACTGGCTAAGCAGCCTTCATGATAATTTCCTTGCACACTTTCCAAACTTGCAAGAGCTCTATGTTAACCATAACCTACTCTCCTTGATCAGTGCAGAGGCTTTCCAAGGGCTTAATAAGCTCTTGAGGCTTCATCTTAATTCCAACCAGCTAAGAGCCATAAGATCAGAGTGGTTCCAGGATCTTTCCCAGCTAGAAATCTTGATGATAGGAGAGAATCCAATTGCCAGAATACAAAACATGAATTTCAAGCCCCTTATCAATCTCCGCAGTCTTGTGCTAACCAGAATGAACCTCACTGAAATCCCTGACAGTGCCCTGGTTGGCCTTMutant Genotyping Size
190Ribosome Profiling Development
Behavior Data
Behavior Data Summary
NoneBehavior Data Description 1
Dark flash block 1 start Merged section Pvalue = 0.0167 12 homhet vs 7 homhom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.pngBehavior Data Graph 1
Behavior Data Description 2
Day all prepulse tap Merged section Pvalue = 0.0178 18 homhet vs 14 homhom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.pngBehavior Data Graph 2
Behavior Data Description 3
Features of movement entire protocol Graph Pvalue = 0.0305 Merged section Pvalue = 0.0269 might not repeat 20 hethet vs 18 homhet ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.pngBehavior Data Graph 3
Behavior Data Description 4
Frequency of movement entire protocol Graph Pvalue = 0.0424 Merged section Pvalue = 0.0199 12 homhet vs 7 homhom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.pngBehavior Data Graph 4
Behavior Data Description 5
Location in well entire protocol Graph Pvalue = 0.0095 Merged section Pvalue = 0.0164 9 hethet vs 7 homhom ribgraph_mean_ribbonbout_averhofrac_10min_combo.pngBehavior Data Graph 5
Behavior Data Description 6
Features of movement Graph Pvalue = 0.001 9 hethet vs 12 homhet ribgraph_mean_ribbonbout_aveboutspeed_10min_day2heatshock.pngBehavior Data Graph 6
Behavior Data Description 7
Frequency of movement Graph Pvalue = 0.00684 12 homhet vs 7 homhom ribgraph_mean_ribbonbout_aveinterboutinterval_10min_combo.pngBehavior Data Graph 7
Behavior Data Description 8
Light flash Graph Pvalue = 0.000635 20 hethet vs 16 hethom boxgraph_pd__ribgraph_mean_ribbon_speedresponse_dist_lightflash104.pngBehavior Data Graph 8
Behavior Data Description 9
Location in well Graph Pvalue = 0.00086 20 hethet vs 18 homhet ribgraph_mean_ribbonbout_centerfrac_10min_combo.pngBehavior Data Graph 9
Behavior Data Description 10
PPI tap Graph Pvalue = 0.0106 20 hethet vs 18 homhet boxgraph_pd__smallmovesribgraph_mean_ribbon_latencyresponse_dpix_shortnightprepulseinhibition100b.pngBehavior Data Graph 10
Behavior Data Description 11
Strong tap Graph Pvalue = 0.0013 12 homhet vs 7 homhom boxgraph_pd__ribgraph_mean_ribbon_displacement_dist_nighttappre102.pngBehavior Data Graph 11
Behavior Data Description 12
Weak tap Graph Pvalue = 0.00411 20 hethet vs 18 homhet boxgraph_pd__ribgraph_mean_ribbon_cumdpixresponse_dpix_nightprepulseinhibition101.pngBehavior Data Graph 12
Behavior Data Description 13
NoneBehavior Data Graph 13
NoneBehavior Data Description 14
NoneBehavior Data Graph 14
None