Gene
Gene Not Within Locus (Nearby
False
Allen Brain

Allen Regions

Published Zebrafish Pehnotype
ZFIN Link
http://zfin.org/search?q=akt3&fq=category%3A%22Gene+%2F+Transcript%22&category=Gene+%2F+Transcript&fq=type%3A%22Gene%22
Allen Link
http://mouse.brain-map.org/gene/show/23550
Locus Rank
Genes in Region
AKT3 SDCCAG8
Associated Snps
rs77149735 chr1_243881945_I rs10803138 rs14403
GWAS Region (hg19)
chr1:243503719-244002945
Ricopili Plot Surrounding Area

Distance On Each Side Of Locus In Above Plot
1 MB
Ricopili Plot

Gwas And Surrounding Region Pic

Gwas Region Pic

Sequence 1
Mutation Area - WT DNA Sequence
tcctagaaacatgggctttgtgtgtgtttccaaagGGATGAGTGGGCAGAGGCGATCCAGATGGTGGCAGATAAACTCCAAAGACAGGAAGAGGAGCGAATCCAGTGTAGTCCCACCTCACAGATAGACAACATGGGAGAGGAGGAGATGGACACGTCTATCAGCCACCACAAACGCAAgtgcctgcacacactgatgtgggagttc
Mutation Area - Mutant DNA Sequence
ttcctagaaacatgggctttgtgtgtgtttccaaagGGATGAGTGGGCAGAGGCGATCCGAGGCGATCAGAGGCGAGATGGACACGTCTATCAGCCACCACAAACGCAAGgtgcctgcacacactgatgtgggagttc
Guide RNA Target Sites
GGCAGAGGCGATCCAGATGGTGG
TAAACTCCAAAGACAGGAAGAGG
ATGTTGTCTATCTGTGAGGTGGG
CAACATGGGAGAGGAGGAGATGG
Genotyping Primers
f, tcctagaaacatgggctttgtgtgtgtttcc
r, gaactcccacatcagtgtgtgcag
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

WT Protein Sequence
MSDVTVVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDADLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEERDEWAEAIQMVADKLQRQEEERIQCS
PTSQIDNMGEEEMDTSISHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSAKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSADAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFTGIDWQDVYDKKLIP
PFKPQVSSETDTRYFDEEFTAQTITITPPEKFDEDGMDCMDNERRPHFPQFSYSASGRE-
Mutant Protein Sequence
MSDVTVVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDADLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEERDEWAEAIRGDQRRDGHVYQPPQTQDNE-
Mutant Genotyping Size
138
Transcript Plot

Sequence 2
Mutation Area - WT DNA Sequence
tttggtcagAGTGTCAGCTGATGAAGACTGAGAGACCGAAACCAAACACCTTCATCATCAGGTGTCTGCAGTGGACCACTGTGATCGAGCGCACCTTCCATGTCGACACGCCAGAGGAGAGgtaaaacacgctaaaacacgcaagctagccaaccaatgaggatgcagtcaacaactgaataacatttacagggcatggaaatccttgatgattgtatctagtgtattgaaggtttaaatagtgcatatattgtggatgaagtgcttgaaaatgtaattgttgcttttataataatttatcctagtaaatagttaataaaaatgatatattcaataattaattagttgttttgtattgagtgaaaagcacatacatgctaaatacataaatgctttgaacacataatagtaaacatgtatatataacagatgaatgataaataaataacatcacttaatgataataataataataataataataatgtttggactgtggggtaaatgggaacacccggagaaaacccacaacaacactgggagaacatgcaaactgacccagctggtactcgcaccagtgaccttcttgcttagaggcaacggtgctaaccactaagccaccgtgtcgccctctgatgcatatcggctaattgaattattctttttttttttgaacCAGGGACGAGTGGGTCGAGGCCATTCAGATGGTGGCAGACAAGCTGGCCAAACAGGAGGAAGAAGGAATCCTGTGTAGCCCAATTTCTCAGATTGAAAACGTCAACGAGGAGGAGATGGACACGTCAACCAGTCATCACAAACGAAAGgtagactctctgccaggagcagaagcgttgtaccttgaggttcacagg
Mutation Area - Mutant DNA Sequence
tttggtcagAGTGTCAGCTGATGAAGACTGAGAGACCGAAACCAAACACCTTCATCATCAGGTGGACCACTGTGATCGAGCGCACCTTCCATGTCGACACGCCAGAGGAGAGgtaaaacacgctaaaacacgcaagctagccaaccaatgaggatgcagtcaacaactgaataacatttacagggcatggaaatccttgatgattgtatctagtgtattgaaggtttaaatagtgcatatattgtggatgaagtgcttgaaaatgtaattgttgcttttataataatttatcctagtaaatagttaataaaaatgatatattcaataattaattagttgttttgtattgagtgaaaagcacatacatgctaaatacataaatgctttgaacacataatagtaaacatgtatatataacagatgaatgataaataaataacatcacttaatgataataataataataataataataatgtttggactgtggggtaaatgggaacacccggagaaaacccacaacaacactgggagaacatgcaaactgacccagctggtactcgcaccagtgaccttcttgcttagaggcaacggtgctaaccactaagccaccgtgtcgccctctgatgcatatcggctaattgaattattctttttttttttgaacCAGGGACGAGTGGGTCGAGGCCATTCAGAAGGAATCCTGTGTAGCCCAATTTCTCAGATTGAAAACGTCAACGAGGAGGAGATGGACACGTCAACCAGTCATCACAAACGAAAGgtagactctctgccaggagcagaagcgttgtaccttgaggttcacagg
Guide RNA Target Sites
TCATCATCAGGTGTCTGCAGTGG
ATGTCGACACGCCAGAGGAGAGg
GGTCGAGGCCATTCAGATGGTGG
CTGGCCAAACAGGAGGAAGAAGG
Genotyping Primers
f, agtgaccttcttgcttagaggcaacg
r, cctgtgaacctcaaggtacaacgc
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

WT Protein Sequence
MNDLNVVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDADLAYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEERDEWVEAIQMVADKLAKQEEEGILCS
PISQIENVNEEEMDTSTSHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGTYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSAKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EEIKFPRTLSADAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFTALDWQDVYDKKLVP
PFMPQVSSETDTRYFDEEFTAQTITITPPEKYDEDGMDAADSERRPHFPQFSYSASGRE-
Mutant Protein Sequence
MNDLNVVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDADLAYPLNNFSVAK
CQLMKTERPKPNTFIIRWTTVIERTFHVDTPEESRDEWVEAIQKESCVAQFLRLKTSTRR
RWTRQPVITNERQ-
In Situ Probe Sequence
AAGCCAGCGGCACGTATTATGCAATGAAGATCCTGAAAAAGGAGGTTATTATTGCCAAGGATGAAGTTGCTCACACACTCACGGAGAGCAGAGTTTTGAAGAACACTAGGCACCCATTTCTAACTTCACTGAAGTATTCCTTTCAGACGAAGGATCGATTATGTTTTGTTATGGAGTATGTGAATGGAGGAGAGTTGTTTTTTCATTTGTCGAGAGAACGAGTGTTTTCGGAGGACAGAACCCGATTCTACGGCGCTGAGATCGTTTCCGCGTTAGATTACTTACACTCAGCGAAGATTGTTTACCGAGACCTGAAGCTGGAAAACCTGATGTTGGATAAAGACGGTCACATAAAGATCACTGATTTCGGCCTGTGTAAGGAGGGCATCACGGACGCCGCCACCATGAAGACGTTCTGTGGGACCCCGGAGTATTTAGCCCCTGAGGTATTGGAGGACAATGATTACGGTAGAGCCGTGGACTGGTGGGGTCTAGGAGTCGTCATGTATGAGATGATGTGTGGACGTCTGCCCTTTTATAACCAGGATCACGAGAAGCTGTTTGAGCTGATTCTGATGGAGGAGATCAAATTTCCCAGAACTCTCTCTGCTGATGCTAAGTCTTTACTGTCTGGCTTACTCATCAAGGACCCCAATAAGAGGCTCGGAGGAGGCCCGGATGATGCTAAAGAAATCATGAGACACAGTTTCTTCACGGCGCTGGACTGGCAGGACGTCTACGACAAAAAGCTGGTGCCGCCATTCATGCCCCAGGTCTCTTCAGA
Mutant Genotyping Size
262
Ribosome Profiling Development

Behavior Data
Behavior Data Summary
None
Behavior Data Description 1
Dark flash block 1 start Merged section Pvalue = 0.014 36 hetandwt vs 15 hom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png
Behavior Data Graph 1

Behavior Data Description 2
Day all prepulse tap Merged section Pvalue = 0.0238 10 wt vs 10 hom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png
Behavior Data Graph 2

Behavior Data Description 3
Features of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = 0.0255 22 wt vs 21 hom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png
Behavior Data Graph 3

Behavior Data Description 4
Frequency of movement entire protocol Graph Pvalue = 2.63e-05 Merged section Pvalue = 0.00674 22 wt vs 21 hom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png
Behavior Data Graph 4

Behavior Data Description 5
Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 18 wt vs 16 hom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png
Behavior Data Graph 5

Behavior Data Description 6
Dark flash Graph Pvalue = 0.0107 36 hetandwt vs 15 hom boxgraph_pd__ribgraph_mean_ribbon_fullboutdatamaxloc_dpix_adarkflash103.png
Behavior Data Graph 6

Behavior Data Description 7
Features of movement Graph Pvalue = 0.001 23 hetandwt vs 10 hom ribgraph_mean_ribbonbout_aveboutcumdpix_min_day1taps.png
Behavior Data Graph 7

Behavior Data Description 8
Frequency of movement Graph Pvalue = 0.001 22 wt vs 21 hom ribgraph_mean_ribbon_dpixsecper_min_day2nightstim.png
Behavior Data Graph 8

Behavior Data Description 9
PPI tap Graph Pvalue = 0.0039 23 het vs 15 hom boxgraph_pd__ribgraph_mean_ribbon_freqresponse_dpix_nightprepulseinhibition100b.png
Behavior Data Graph 9

Behavior Data Description 10
Strong tap Graph Pvalue = 0.00162 61 hetandwt vs 16 hom boxgraph_pd__ribgraph_mean_ribbon_timeresponse_dpix_nighttappost102.png
Behavior Data Graph 10

Behavior Data Description 11
Tap habituation Graph Pvalue = 0.000991 36 hetandwt vs 15 hom boxgraph_pd__smallmovesribgraph_mean_ribbon_speedresponse_dist_cdaytaphab102.png
Behavior Data Graph 11

Behavior Data Description 12
Weak tap Graph Pvalue = 0.0135 13 wt vs 15 hom boxgraph_pd__smallmovesribgraph_mean_ribbon_peakspeed_nightprepulseinhibition101.png
Behavior Data Graph 12

Behavior Data Description 13
None
Behavior Data Graph 13
None
Behavior Data Description 14
None
Behavior Data Graph 14
None