schizophrenia gene search

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SLC32A1
PPP1R16B

Locus Rank

Gene

169

Gene Name

PPP1R16B

Duplicated

False

Maternal

False

Gene Not Within Locus (Nearby

False

Gene Description

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1.

Mouse Phenotype

Additional Image

Allen Brain

Allen Regions

Zfin In Situ

Zfin Brain Areas

Published Zebrafish Pehnotype

Not In Allen Brain

False

ZFIN Link

http://zfin.org/ZDB-GENE-131127-294

Allen Link

http://mouse.brain-map.org/gene/show/86795

More Additional Images

Papers

http://www.ncbi.nlm.nih.gov/pubmed/12638124

Locus Rank

Genes in Region

ACTR5 PPP1R16B SLC32A1 FAM83D DHX35

Associated Snps

rs6065094

GWAS Region (hg19)

chr20:37361494-37485994

Genes Skipping

ACTR5 - not in brain at all, DNA repair; FAM83D - mitosis, cancer, not in zebrafish brain; DHX35 - likely RNA helicase, not in allen brain

Ricopili Plot Surrounding Area

Distance On Each Side Of Locus In Above Plot

1 MB

Ricopili Plot

Gwas And Surrounding Region Pic

Gwas Region Pic

Genes In Locus Rank

SLC32A1
PPP1R16B

Sequence 1

Ensembl Gene Name

PPP1R16B

Harvard Allele

a324

Mutation Area - WT DNA Sequence

gacagGCATCACGCAGGAGATGATCAATGAGACGAGAGCGGCAGTGGAGCGGAGCATGCTGGGAGATATTCAGAAGATCCTGCAGGAGGGAGCGGACGTCAACCATCACGACTCACAGGGGGCCACGCTGgtacacacacattcagtcatacacagacagatactaacttagacacacacacattcagtcacagacagacacacccatgcataaatgcacagacgcatacatgcgcacacacagacatacacacacatgcacatacacatacatgcatacacacaaacacatacacacgcactcagtcatacacacacacacacacattcagtagcagacagacacacacttgcacatacatgcatacacacacacactttcagtagatacacactcatgcatacacgcacacacatacacacacacacacacacacacacacgcatatacaaacacacacacaaacacacacattcagtcatagacacacatacacatgtgcacacacacacttaaacacacatacttacgaaatatatgcatgtgtgtgtgtgtgtgtgtatttgtgtgtgttttcagCTGCACATCGCATCAGCAAACGGTTATACTCAGGCTGCAGAGCTGCTCTTAGACGCCGGAGCTCGATCAGACATGAGAGACTCAGACGGATGGACACCACTGCACGCTGCTGCATGCTGGG

Mutation Area - Mutant DNA Sequence

gacagGCATCACGCAGGAGATGATCAATGAGACGGATGGACACCACTGCACGCTGCTGCATGCTGGG

Guide RNA Target Sites

TCTCATGTCTGATCGAGCTCCGG
TCAACCATCACGACTCACAGGGG
GATGATCAATGAGACGAGAGCGG
TCAGACATGAGAGACTCAGACGG

Genotyping Primers

f, gacagGCATCACGCAGGAGATG
r, CCCAGCATGCAGCAGCGTGC
wt_f, GCAAACGGTTATACTCAGGCTGCA
Three primers can be mixed together

Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

Allele

634bpD

WT Genotyping Size

106

WT Protein Sequence

MVQILLTHGATVNAQDNELWTPLHAAATCGHTGLVKILIQHGADLLAVNSDGNMPYDLCE
DDPTLDIIETAMANRGITQEMINETRAAVERSMLGDIQKILQEGADVNHHDSQGATLLHI
ASANGYTQAAELLLDAGARSDMRDSDGWTPLHAAACWGQVQVAELLVSHGASLNAKTYME
ETPIDLCEDEEFRNHLLELKHKHDIIMKSQLKHKTSLCRRTSSAGSRGKVVRRASLSDRH
NLCRKEYQTEAIVWRGGREKEERERESDQENSHTMQPTEGPQSPGILKDSGQNGCISSPS
PNGDPLTPPDPMTPPVPGDPVTSAEEPKLKAQTLSELKKQRSAAAAKLLHHPVLNGHLGN
GSSKPLPDDPRMPLVSSNGSAVYFTPASGDPPLLRFKQPIEEEDPKSHSCCCIA-

Mutant Protein Sequence

MVQILLTHGATVNAQDNELWTPLHAAATCGHTGLVKILIQHGADLLAVNSDGNMPYDLCE
DDPTLDIIETAMANRGITQEMINETDGHHCTLLHAGDRFKWRSCWFLMEPV-

Mutant Genotyping Size

Ribosome Profiling Development

Behavior Data

Behavior Data Summary

None

Behavior Data Description 1

Dark flash block 1 start Merged section Pvalue = not significant 47 het vs 44 hom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png

Behavior Data Graph 1

Behavior Data Description 2

Day all prepulse tap Merged section Pvalue = not significant 47 het vs 44 hom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png

Behavior Data Graph 2

Behavior Data Description 3

Features of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 47 het vs 44 hom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png

Behavior Data Graph 3

Behavior Data Description 4

Frequency of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 47 het vs 44 hom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png

Behavior Data Graph 4

Behavior Data Description 5

Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 47 het vs 44 hom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png

Behavior Data Graph 5

Behavior Data Description 6

None

Behavior Data Graph 6

None

Behavior Data Description 7

None

Behavior Data Graph 7

None

Behavior Data Description 8

None

Behavior Data Graph 8

None

Behavior Data Description 9

None

Behavior Data Graph 9

None

Behavior Data Description 10

None

Behavior Data Graph 10

None

Behavior Data Description 11

None

Behavior Data Graph 11

None

Behavior Data Description 12

None

Behavior Data Graph 12

None

Behavior Data Description 13

None

Behavior Data Graph 13

None

Behavior Data Description 14

None

Behavior Data Graph 14

None