schizophrenia gene search

Made

DOC2A
KCTD13
SYBU
SEZ6L2

Locus Rank

Gene

181

Gene Name

DOC2A

Duplicated

False

Maternal

False

Gene Not Within Locus (Nearby

False

Gene Description

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.

Mouse Phenotype

Additional Image

Allen Brain

Allen Regions

Zfin In Situ

Zfin Brain Areas

Published Zebrafish Pehnotype

Not In Allen Brain

False

ZFIN Link

http://zfin.org/ZDB-GENE-090706-1

Allen Link

http://mouse.brain-map.org/gene/show/13225

More Additional Images

Papers

Locus Rank

Genes in Region

ALDOA ASPHD1 C16orf92 DOC2A FAM57B GDPD3 HIRIP3 INO80E KCTD13 MAPK3 PPP4C SEZ6L2 TAOK2 TBX6 TMEM219 YPEL3

Associated Snps

rs12691307

GWAS Region (hg19)

chr16:29924377-30144877

Genes Skipping

ALDOA - definitely not; ASPHD1 - not in allen brain, and very unlikely; C16orf92 - nothing is known; FAM57B - hard to know, very little is known; GDPD3 - nothing in allen brain; HIRIP3 - histones; INO80E - maybe, but seems not that likely; MAPK3 - maybe; PPP4C - maybe, very unlikely; TAOK2 - maybe, but not in allen brain; TBX6 - not in allen brain, involved in development; TMEM219 - seems very unlikely, not in allen brain; YPEL3 - no.

Ricopili Plot Surrounding Area

Distance On Each Side Of Locus In Above Plot

0.2 MB

Ricopili Plot

Gwas And Surrounding Region Pic

Gwas Region Pic

Genes In Locus Rank

DOC2A
KCTD13
SYBU
SEZ6L2

Sequence 1

Ensembl Gene Name

doc2a

Harvard Allele

a263

Mutation Area - WT DNA Sequence

ggatcatttaatctgcttcctgacaggttttatatatacgttattgatgctattaatgtgcacattatcattcctgtgattgtgtagCTGCGCTGGGGACGCTAGAGTTCGAACTGAGGTATGAGAAAGCCACCAGTTCACTCAACTGCACCATCATCAGAGCAAAGgtaacgtctatctcacacctctgcacttcactacacacacacaaacactcacacctgtgcgtgactcacacacactcaaaacctgcaggtgatttaccctttagctgtttgttttatttcagcagggctccaacacaccattgtttctttatgctttttattcagcagcctggtcaagtaaatcattgtgtgttatttttttatttagGGTTTGAAACCCATGGATTTTAATGGCCTGGCTGACCCTTATGTCAAACTTCATCTTCTACCAGGAGCATGCAAGgtgggcaagcttagatcttgttttgtgccaattaaaacttttaatgcataagttttaatgaggcattttaaaaattcatgatgttttattttgtccaaacaactattctctttgatagcctaagctcattatacactttctgg

Mutation Area - Mutant DNA Sequence

GGATCATTTAATCTGCTTCCTGACAGGTTTTATATATACGTTATTGATGCTATTAATGTGCACATTATCATTCCTGTGATTGTGTAGCTGCGGAGTTCACTCAACTGCACCATCATCAGAGCAAAGGTAACGTCTATCTCACACCTCTGCACTTCACTACACACACACAAACACTCACACCTGTGCGTGGCTCACA

Guide RNA Target Sites

gtgattgtgtagCTGCGCTGGGG
TCTACCAGGAGCATGCAAGgtgg
GGTGCAGTTGAGTGAACTGGTGG
GGACGCTAGAGTTCGAACTGAGG

Genotyping Primers

f, ggatcatttaatctgcttcctgacagg
r, ccagaaagtgtataatgagcttaggctatc

Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

Allele

41bpD

WT Genotyping Size

593

WT Protein Sequence

MTVRKGKKLTISIQEHMAIDVCPGPIRPIRQISAYFPRLSPTAEPVSPNPASPLSLSPGL
GASGGASGGLLSPLQAGARGGGGTLSAASSIETSVDICSSDSDDSTALGTLEFELRYEKA
TSSLNCTIIRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTVRNSLNPVWNETLTY
VGITEEDMHRKTLRLSVCDEDKLTHNEFIGESRVALRRVKPDQTKRFYTCLEHPPPLPSP
TAMGAALRGISCYLREWENEQMTSLEERGRLLLSLQFLPPPAEGEGESRRGGLCVGVLRC
AHLAAMDVNGFSDPYVKIYLKPDVKKKSKHKTSVIKKTLNPEFNEEFFYEISLSELVHKT
LEVTVWDYDLGRSNDFIGGVCLSCHVQGDALRHWMDCLRNKGQRVERWHILANELPQTTC
HD-

Mutant Protein Sequence

MTVRKGKKLTISIQEHMAIDVCPGPIRPIRQISAYFPRLSPTAEPVSPNPASPLSLSPGL
GASGGASGGLLSPLQAGARGGGGTLSAASSIETSVDICSSDSDDSTAEFTQLHHHQS
KGFETHGF-

Mutant Genotyping Size

552

Ribosome Profiling Development

Behavior Data

Behavior Data Summary

None

Behavior Data Description 1

Dark flash block 1 start Merged section Pvalue = not significant 16 het vs 14 hom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png

Behavior Data Graph 1

Behavior Data Description 2

Day all prepulse tap Merged section Pvalue = not significant 16 het vs 14 hom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png

Behavior Data Graph 2

Behavior Data Description 3

Features of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 16 het vs 14 hom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png

Behavior Data Graph 3

Behavior Data Description 4

Frequency of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 16 het vs 14 hom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png

Behavior Data Graph 4

Behavior Data Description 5

Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 16 het vs 14 hom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png

Behavior Data Graph 5

Behavior Data Description 6

None

Behavior Data Graph 6

None

Behavior Data Description 7

None

Behavior Data Graph 7

None

Behavior Data Description 8

None

Behavior Data Graph 8

None

Behavior Data Description 9

None

Behavior Data Graph 9

None

Behavior Data Description 10

None

Behavior Data Graph 10

None

Behavior Data Description 11

None

Behavior Data Graph 11

None

Behavior Data Description 12

None

Behavior Data Graph 12

None

Behavior Data Description 13

None

Behavior Data Graph 13

None

Behavior Data Description 14

None

Behavior Data Graph 14

None