Gene
Gene Not Within Locus (Nearby
False
Allen Brain

Allen Regions

Published Zebrafish Pehnotype
ZFIN Link
http://zfin.org/ZDB-GENE-091204-189
Allen Link
http://mouse.brain-map.org/gene/show/87745
Locus Rank
Genes in Region
ALDOA ASPHD1 C16orf92 DOC2A FAM57B GDPD3 HIRIP3 INO80E KCTD13 MAPK3 PPP4C SEZ6L2 TAOK2 TBX6 TMEM219 YPEL3
Associated Snps
rs12691307
GWAS Region (hg19)
chr16:29924377-30144877
Genes Skipping
ALDOA - definitely not; ASPHD1 - not in allen brain, and very unlikely; C16orf92 - nothing is known; FAM57B - hard to know, very little is known; GDPD3 - nothing in allen brain; HIRIP3 - histones; INO80E - maybe, but seems not that likely; MAPK3 - maybe; PPP4C - maybe, very unlikely; TAOK2 - maybe, but not in allen brain; TBX6 - not in allen brain, involved in development; TMEM219 - seems very unlikely, not in allen brain; YPEL3 - no.
Ricopili Plot Surrounding Area

Distance On Each Side Of Locus In Above Plot
0.2 MB
Ricopili Plot

Gwas And Surrounding Region Pic

Gwas Region Pic

Sequence 1
Mutation Area - WT DNA Sequence
TTCAGTGCAATGCCAGTCTGTCAGGAATGGAGGGAATAATCGAGTCTCCTGATCCGCTCTCATCCTCGTCTGCCTTTTCCCCACTGGAGTGCACCTACAGCATCACCGTCTATCCTGGATATGGCGTTGAGATACAGgtgggattgcctccctatttccagtttacagctctagcctctgtataggtatagctggtgtatctggttggcatttgcatgggtgatgtcactctaaagagttcaggaatctttgctcttgatacactcttgcgtaacgacatcattagctgttgttatggtaacatcacccatctgtcttgaagGTGAAGAAAGTAAACTTGTCCAAAGAGGAGTCCCTCACCATTTCGGATCTGGGTGGTGCAGCACTTGAGGTTTTGGCCAATGAGACGCTGATGAGCGAAGGTCAGGTGATTCGTAGCACAACCAATCAAGTGCAGATCCATTATAAGAGCCTGAAGCAAAACAATCATGGCGTTTTCAGCTTTCACTATCAAGgtatgttacttgggtacaaagtatgtttagggtctacatatacatgattgtaacatgtcttttttgatttgccagctgtaaccgaaatgtctttttcttttgaacaccaattccagCCTTCCTCCTGTCCTGTTCGTTCCCTCTCTCCCCTGAGGGCGGCGGAGTGACTGTAACTGATATACATCCTGGCGGTCAGGCTCACTTTCATTGTGATCCAGGGTTTGAGGTCAGAGGTCATGAGGTTGCAACCTGTTTAAACTCTACCCGACCCAAATGGAGCACTCCAGAGCCCCAGTGTGTTGgtgggttgcattgatttttgttatttgaatgtctttcatttgctcaaatacacctctgctcgttgccatgtgtac
Mutation Area - Mutant DNA Sequence
TTCAGTGCAATGCCAGTCTGTCAGGAATGGAGGGAATAATCGAGTCTCCTGATCCGCTCTCATCCTCGTCTGCCTTTTCCCCACTGGAGTGCATGAGGTCAGAGGTCATGAGGTTGCAACCTGTTTAAACTCTACCCGACCCAAATGGAGCACTCCAGAGCCCCAGTGTGTTGgtgggttgcattgatttttgttatttgaatgtctttcatttgctcaaatacacctctgctcgttgccatgtgtac
Guide RNA Target Sites
GCTGTAGGTGCACTCCAGTGGGG
CTCACCATTTCGGATCTGGGTGG
AATGAGACGCTGATGAGCGAAGG
GATCCAGGGTTTGAGGTCAGAGG
Genotyping Primers
f, TTCAGTGCAATGCCAGTCTGTCAGG
r, gtacacatggcaacgagcagaggtg
wt_r, GTGAGGGACTCCTCTTTGGACAAG
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

WT Protein Sequence
MVSTVFAVTLSVTLLHLASGASLGTSDPEAPPTVTSSPRPLGDLIHAALLSKEYLGHTPG
SRGTTTNPTQAVPSIKESEPASTVMSPGILTTAVTSSAVPQAGQLGFGGAVTSLPAEEET
TTTLITTTTITTVHTPVQCNASLSGMEGIIESPDPLSSSSAFSPLECTYSITVYPGYGVE
IQVKKVNLSKEESLTISDLGGAALEVLANETLMSEGQVIRSTTNQVQIHYKSLKQNNHGV
FSFHYQAFLLSCSFPLSPEGGGVTVTDIHPGGQAHFHCDPGFEVRGHEVATCLNSTRPKW
STPEPQCVAVSCGGWIRNATVGRILSPTLPSASNHSSGSNLSCHWLLEAKEGHRLHLHFE
RVALDEDNDKLIVRSGNSTTAPLLFDSDLDDVPERGFVSEGSSLFVELTADSSSIPLLLA
LRYEAFDGEHCYEPYLPHGNFSSSDITFPLGTVVSFSCAAGFVMEQGSGVMECLDPNDPH
WNETEPVCRALCGGELTDPVGTVLSPDWPQSYSKGQDCVWQIHVSEDKRIELDVQILNIR
HNDVLTLFDGHDLMSHVIGQYMGSRERFRVVSGGSEVTIQFQSDPDDSTFILSQGFLIHY
REVEPNDTCSALPQIEFGWSSSSHPSLVRGSVLTYQCQPGYDIVGSDIITCQWDLTWSNS
PPTCVKIQQCPDPGEVVNGARSVHPESGFAVGTVVRFTCNQGYQLEGPSQISCHGRDTGM
PKWSDRSPKCVLKYDPCPNPGVPDNGYQTLYKHSYQAGETLRFFCYEGYELIGEVIINCV
PGHPSQWNSPPPFCKVAYEGLLDDHKLEVSQSLDASHQMLSENIALAIILPIILVILLIG
GIYMYYTNVCRWQWKPMFWKSLSHTHSYSPITVESDFNNPLYEAGDTREYEVSI-
Mutant Protein Sequence
MVSTVFAVTLSVTLLHLASGASLGTSDPEAPPTVTSSPRPLGDLIHAALLSKEYLGHTPG
SRGTTTNPTQAVPSIKESEPASTVMSPGILTTAVTSSAVPQAGQLGFGGAVTSLPAEEET
TTTLITTTTITTVHTPVQCNASLSGMEGIIESPDPLSSSSAFSPLECMRSEVMRLQPV-
Mutant Genotyping Size
248
Ribosome Profiling Development

Behavior Data
Behavior Data Summary
None
Behavior Data Description 1
Dark flash block 1 start Merged section Pvalue = not significant 17 het vs 25 hom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png
Behavior Data Graph 1

Behavior Data Description 2
Day all prepulse tap Merged section Pvalue = 0.0382 17 het vs 25 hom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png
Behavior Data Graph 2

Behavior Data Description 3
Features of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 17 het vs 25 hom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png
Behavior Data Graph 3

Behavior Data Description 4
Frequency of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 17 het vs 25 hom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png
Behavior Data Graph 4

Behavior Data Description 5
Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 17 het vs 25 hom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png
Behavior Data Graph 5

Behavior Data Description 6
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Behavior Data Graph 6
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Behavior Data Description 7
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Behavior Data Graph 7
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Behavior Data Description 8
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Behavior Data Graph 8
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Behavior Data Description 9
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Behavior Data Graph 9
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Behavior Data Description 10
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Behavior Data Graph 10
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Behavior Data Description 11
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Behavior Data Graph 11
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Behavior Data Description 12
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Behavior Data Graph 12
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Behavior Data Description 13
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Behavior Data Graph 13
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Behavior Data Description 14
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Behavior Data Graph 14
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